Production-Single-Use-Chromatography-System

Single-use chromatography systems for full-scale production

The Agilitech Advantage:

Flexible system design with configurable flow path – provides unmatched flexiblity to meet your precise requirements

Dual inlet headers with dedicated flow sensors – deliver accurate control throughout inline dilution and gradient steps

Dual filter manifold – reduces risk of protein aggregation and eliminates the need for bubble traps

Outlet back pressure control valve – enables offline column pressure simulation to stabilize pumps and smooth transition to inline columns

State-of-the-art automation and control

Home | Chromatography Systems

Designed to meet your specific bioprocess requirements

A unique system design provides complete flexibility to meet your exact process requirements, while every part of the system features best-in-class components to optimize performance. Our standard systems can be customized to meet your exact production requirements. This includes re-configuring the flow path to add more filters, outlets, and/or buffers. The brand-agnostic design gives you the freedom to choose your preferred brand of column, filters, and other components, as well as the automation and control platform— whether that’s DeltaV, Rockwell Automation, or another platform.

Engineered to optimize your bioprocess

Agilitech single-use chromatography systems feature a unique open system design that takes flexibility to the next level. Our engineering experts work with you to understand your specific needs and adapt the standard system design to fit your process.

Maximum flexibility

  • Open system design with configurable flow path – provides unmatched flexiblity
  • Brand-agnostic design gives you the freedom to choose your preferred brand of column and other components
  • Custom single-use assembly accommodates Sartorius, Millipore, Pall, and other preferred filter brands

Single-use technology ensures a safe and sterile process

  • Fully sterilized single-use tubing sets, complete with integrated sensors, minimize risk of contamination
  • Sterile-to-sterile connections for inlets/outlets reduce contamination risks
  • Highest quality components; USP <88> Class VI certified single-piece tubing sets ensure sterility throughout use

Delivered with your preferred automation and control system

Choose the automation and control platform that fits your needs best. Our engineering experts have years of experience with DeltaV, Rockwell Automation, and other leading platforms; we can integrate the system to meet your requirements. Regardless of the platform you choose, the user experience is the same due to the ISA-88 batch-compliant structure that is used to create the building blocks of the automation.

Easy-to-use, intuitive control panel

The user friendly control panel is exceptionally easy to use. Our engineers have listened to customer needs and have identified the functions and data that operators need to access most often; the user interface brings these functions and data to the top layer of the screen to eliminate endless clicking or digging for critical information.

 

Agilitech Chromatography System Control Panel

Single-Use Chromatography Models

Technical Specifications

Attribute C500 C750 C1000
General Skid Specifications
Tubing ID 0.50 in 0.75 in 1.0 in
Flow Rates 0.167-15 LPM 0.167-20 LPM 0.8-41 LPM
Pressure 0-60 psi/4 bar 0-60 psi/4 bar 60 psi/4 bar
pH 0-14 pH 0-14 pH 0-14 pH
Conductivity 0-250 mS/cm 0-250 mS/cm 0-250 mS/cm
UV Wavelength 0-2AU Dual Wavelength-280 nm and 300 nm standard. Customer configurable to any 2 wavelengths between 254-313 nm 0-2AU Dual Wavelength – 280 nm and 300 nm standard. Customer configurable to any 2 wavelengths between 254-313 nm 0-2AU Dual Wavelength – 280 nm and 300 nm standard. Customer configurable to any 2 wavelengths between 254-313 nm
Temperature Range 2-50°C 2-50°C 2-50°C
Humidity (non-condensing) 10-90% 10-90% 10 – 90%
Utility Required, Skid Power* 220-230 VAC 220-230 VAC 220-230 VAC
Wetted Materials USP <88> Classs VI and animal free USP <88> Class VI and animal free USP <88> Class VI and animal free
Inlets 8 (4 ea inlet header) 8 (4 ea inlet header) 8 (4 ea inlet header)
Outlets 2 2 2
Flow Accuracy ±3% ±3% ±3%
Hold-Up Volume – Inlet to Column 1.33 L 2 L 3.5 L
Hold-Up Volume – Column to Outlet 0.55 L 0.75 L 1.25 L
Dims (W x D x H)** 910 x 910 x 1025 mm 1622 x 1422 x 1816 mm 1622 x 1422 x 1816 mm
Sensor Performance
Pressure 0-6 psi (± 2%)
6-30 psi (± 3%)
30-60 psi (± 5%)
0-6 psi (± 2%)
6-30 psi (± 3%)
30-0 psi (± 5%)
0-6 psi (± 2%)
6-30 psi (± 3%)
30-60 psi (± 5%)
Conductivity 0-250 mS/cm (±0.25 mS/cm) 0-250 mS/cm (±0.25 mS/cm) 0-250 mS/cm (±0.25 mS/cm)
Flow 0-20 LPM (± 3%) 0-50 LPM (± 3%) 0-100 LPM (± 3%)
pH 0-14 (± 0.1) 0-14 (± 0.1) 0-14 (± 0.1)
UV 0-2 AU (± 2%) 0-2 AU (± 2%) 0-2 AU (± 2%)

*Compressed air (oil free) @ 80 psi/5.5 bar
**Highest Operator interaction: 5 ft 2 in

Specifications represent standard Agilitech models and may change when customized for specific customer applications. Specifications subject to change without notice.

Quality manufacturing backed by world-class service and support

All Agilitech single-use TFF systems are manufactured to the highest standards and delivered with the documentation you need:

  • Standard Factory Acceptance Testing (FAT) and Site Acceptance Testing (SAT) documentation provided upon delivery; we can also use your specific documentation, if preferred
  • Installation Qualification (IQ) and Operational Qualification (OQ) testing and documentation available for use in cGMP production

If needed, we will partner with you to develop Performance Qualification (PQ) testing; supplemental documents such as Qualification Project Plan (QPP), Criticality Assessment and Risk Assessment can also be provided.

All Agilitech single-use chromatography systems are delivered with a recommended preventative maintenance plan and spare parts list. We also provide maintenance service to ensure pumps, transmitters and all other components function within specification.

You have a vision for your process.

We can help you get there.