How a biologics manufacturer managed to scale up production and double throughput with a flexible dual-filter TFF system.

Agilitech Case Study:  Tangential Flow Filtration (TFF) System

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Optimizing a Tangential Flow Filtration (TFF) System for Biologics Manufacturing with Future-proof Single-Use Technology

A recognized world leader in the discovery and production of enzymes for molecular biology applications was in need of a new tangential flow filtration (TFF) system to support production of a cell-based product. Their production process depended on accurate TFF, an essential step for washing their material before preparing the product for market. As a commercial product, and not a research product, this particular production line was essential to the company’s customers and their overall revenue stream. The company outgrew its TFF system as demand for the product flourished; the process engineering team realized they would not be able to increase product volume in a timely and cost effective way without a new TFF solution. While their existing single-use TFF system and bioreactor worked effectively when their demand was lower, higher volumes required the client to run their system weekly as opposed to bi-monthly in order to keep up with production. Frequent processing runs meant increased costs for disposables that were becoming more and more difficult to procure due to Covid-19 related disruptions in the supply chain. Learn how Agilitech applied its flexible design approach in collaboration with the customer to provide a TFF solution that meets current and future needs, and also helped to address supply chain issues with single-use components.

Read the case study to learn more about:

A transformative bioprocess product design process that results in true fit-for-purpose solutions tailored to unique process requirements

Brand-agnostic tangential flow filtration systems that can be adapted to meet unique bioprocess needs

Future-proofing bioprocesses with flexible, brand-agnostic single-use systems that offer more options when faced with supply chain issues of single-use components

About the Author:


Dennis Hodgson is Director, Biotech, at Agilitech, providing technical leadership for new product development, as well as custom configurations of Agilitech’s biotech products and systems to meet the unique and specific needs of each client – today and in the future. With over 16 years of engineering/manufacturing experience working at preeminent global companies such as Genentech, Novartis Pharmaceuticals, and Boehringer Ingelheim, Dennis is well versed in all functional areas of biotech process design and engineering. He also has broad experience with bioprocess system integration, automation and process optimization, and is proficient with multiple market-leading automation platforms such as DeltaV and Rockwell Automation. Dennis’ vast expertise and understanding of the ever-changing arena of biotech research and development, as well as biopharmaceutical manufacturing are sought after by both internal colleagues and clients alike.

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As a pioneering partner to the biotech industry, Agilitech helps to drive progress by designing and implementing state-of-the-art equipment and bioprocessing systems for biotech labs through to full-scale production, along with providing game-changing bioprocess engineering and automation services.

In a fast-moving industry that is constantly evolving, Agilitech has the flexibility and experience to tailor its offerings to the specific requirements of each and every customer. A transformative product design and engineering process is what makes Agilitech single-use products unique and ensures that the company’s solutions meet the exact needs of each and every customer. Through front-end planning and collaborative product design with their customers, Agilitech delivers truly fit for purpose solutions to real problems.

Watch the Agilitech video to learn more and visit the Agilitech website to learn about the game-changing single-use bioprocessing technologies described in this article.

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